Free Fatty Acid Receptor
FFAR
Free fatty acid receptors (FFARs) are G protein-coupled receptors (GPCRs) activated by free fatty acids (FFAs). The four well-characterized FFARs are FFAR1/GPR40, FFAR2/GPR43, FFAR3/GPR41, and FFAR4/GPR120. FFARs are categorized according to the chain length of FFA ligands that activate each FFAR; FFA2 and FFA3 are activated by short chain FFAs, mainly acetate, butyrate, and propionate. GPR84 is activated by medium-chain FFAs, whereas FFA1 and GPR120 are activated by medium- or long-chain FFAs. Thus, each FFAR can act as an FFA sensor with selectivity for a particular FFA carbon chain length derived from food or food derived metabolites. FFARs have been reported to have physiological functions such as facilitation of insulin and incretin hormone secretion, adipocyte differentiation, anti-inflammatory effects, neuronal responses, and taste preferences. These physiological functions of FFARs could be considered to regulate energy and immune homeostasis. Therefore, FFARs have been targeted in therapeutic strategies for the treatment of metabolic disorders including type 2 diabetes and metabolic syndrome.
Free Fatty Acid Receptor Isoform Specific Products
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Free Fatty Acid Receptor Inhibitors
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Free Fatty Acid Receptor Agonists
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Free Fatty Acid Receptor Antagonists
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Free Fatty Acid Receptor Activators
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Free Fatty Acid Receptor Modulators
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Free Fatty Acid Receptor Controls
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Free Fatty Acid Receptor Ligand
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Free Fatty Acid Receptor Related Products (131)
Related Products (131)
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Antibodies (4)
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Free Fatty Acid Receptor Isoform Comparison
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BMS-986118
0 ImagesCat. No.: HY-12413ACAS No.: 1610562-74-7BMS-986118 is a potent, orally active, and selective GPR40 agonist with an EC50 of 0.07 µM. BMS-986118 has dual insulinotropic and GLP-1 secretory effects, resulting in robust plasma glucose lowering effects in acute animal models.
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AP5 sodium
0 ImagesCat. No.: HY-112603ACAS No.: 1623143-67-8AP5 sodium is a potent, orall active, and selective GPR40 receptor agonist with a positive allosteric modulation of endogenous ligand (AgoPAM). AP5 sodium demonstrates rat and human inositol monophosphate (IP1) EC50 values of 0.49 nM and 0.8 nM against the GPR40 receptor, respectively. AP5 sodium has the potential for type II diabetes research.
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AS2034178 free base
0 ImagesCat. No.: HY-P1124CAS No.: 1030846-42-4AS2034178 free base, a specific and orally active GPR40 agonist, exhibits glucose-dependent insulin secretion enhancement. AS2034178 free base has potential for type 2 diabetes mellitus research.
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LXT34
0 ImagesCat. No.: HY-176838CAS No.: 1609286-95-4LXT34 (Example 2) is a GPR120 agonist. LXT34 has an anti-inflammatory activity. LXT34 promotes GLP-1 formation in the gastrointestinal tract and improves insulin resistance in macrophages and pancreas cells. LXT34 can be used for inflammatory diseases, such as type 2 diabetes, obesity and non-alcoholic fatty liver research.
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FFA1 agonist-1
0 ImagesCat. No.: HY-147987CAS No.: 2417231-16-2FFA1 agonist-1 (Compound 17a) is an orally active fatty acid receptor 1 (FFA1) agonist with an EC50 of 0.75 μM. FFA1 agonist-1 can be used for type 2 diabetes mellitus research.
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GPR40 agonist 8
0 ImagesCat. No.: HY-177296CAS No.: 1905451-62-8
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LY2881835
0 ImagesCat. No.: HY-108020CAS No.: 1292290-38-0LY2881835 is a potent and selective agonist of G protein-coupled receptor 40 (GPR40). LY2881835 has efficacious and durable dose-dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion. LY2881835 has the potential for the research of type 2 diabetes mellitus. LY2881835 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
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Metabolex-36
0 ImagesCat. No.: HY-135763CAS No.: 1224102-50-4Synonyms: Met-36Metabolex-36 is a FFA4 agonist with a pEC50 value of 5.9 and a pEC50 value of less than 4.0 for FFA1.
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Anticancer agent 316
0 ImagesCat. No.: HY-182404CAS No.: 337495-81-5Anticancer agent 316 (Compound 1) is an anticancer agent. Anticancer agent 316 exerts anticancer activity against colorectal cancers expressing GPR120. Anticancer agent 316 can be used in the research of colorectal cancer.
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FFAR4 agonist-1
0 ImagesCat. No.: HY-185937CAS No.: 3110207-82-1
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FFA2 agonist-2
0 ImagesCat. No.: HY-182729CAS No.: 1229363-11-4FFA2 agonist-2 is a potent agonist of the FFA2 (GPR43) receptor, with a pEC50 of 7.9 for human FFA2, and a pEC50 of 7.3 for murine FFA2. FFA2 agonist-2 acts as an orthosteric agonist and shows no obvious cross‑activity against FFA1, FFA3 and FFA4. FFA2 agonist-2 can be used for FFA2 receptor research in type 2 diabetes and metabolic disorders.
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AM-3189
0 ImagesCat. No.: HY-111141CAS No.: 916219-50-6AM-3189 is an orally active and selective GPR40 agonist with EC50 values in buffer solution and in 100% human serum of 33 nM and 10 μM respectively. AM-3189 shows no significant activity on GPR41 and GPR43, and no agonistic activity on PPAR-α, -δ, and -γ. AM-3189 enhances glucose-stimulated insulin secretion by activating GPR40 on pancreatic β cells. AM-3189 has extremely low penetration into the central nervous system and significantly reduces blood glucose levels in two humanized GPR40 mouse models. AM-3189 can be used for the study of type 2 diabetes.
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Icosabutate (Standard)
0 ImagesCat. No.: HY-121212RCAS No.: 1253909-57-7Desmethyl Sibutramine (hydrochloride) (Standard) is the analytical standard of Desmethyl Sibutramine (hydrochloride). This product is intended for research and analytical applications. Icosabutate is an orally active engineered fatty acid and a dual FFAR1/FFAR4 (GPR40/GPR120) agonist with EC50 values of 10 μM and 15.5 μM, respectively. Icosabutate acts as a partial agonist of PPAR-α, with an EC50 of 208 nM. Icosabutate inhibits the arachidonic acid cascade and exhibits antioxidant and anti-apoptotic activities. Icosabutate can be used in the research of nonalcoholic steatohepatitis, metabolic dysfunction-associated steatohepatitis, and atherosclerosis.
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GPR41 modulator 1
0 ImagesCat. No.: HY-163530CAS No.: 3050768-93-6GPR41 modulator 1 (compound 10ak) is a potent GPR41 modulator with an EC50 value of 0.679 µM. GPR41 modulator 1 shows agonistic modulator activity.
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TUG-891 (Standard)
0 ImagesTUG-891 (Standard) is the analytical standard of TUG-891. This product is intended for research and analytical applications. TUG-891 is a potent and selective agonist for the long chain free fatty acid (LCFA) receptor 4 (FFA4/GPR120).
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GW-1100 (Standard)
0 ImagesCat. No.: HY-50691RCAS No.: 306974-70-9GW-1100 (Standard) is the analytical standard of GW-1100. This product is intended for research and analytical applications. GW-1100 is a selective GPR40 antagonist with a pIC50 of 6.9.
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Vincamine (Standard)
0 ImagesVincamine (Standard) is the analytical standard of Vincamine. This product is intended for research and analytical applications. Vincamine is a monoterpenoid indole alkaloid extracted from the Madagascar periwinkle. Vincamine is a peripheral vasodilator and exerts a selective vasoregulator action on the brain microcapilar circulation. Vincamine is a GPR40 agonist and acts as a β-cell protector by ameliorating β-cell dysfunction and promoting glucose-stimulated insulin secretion (GSIS). Vincamine improves glucose homeostasis in vivo, and has the potential for the type 2 diabetes mellitus (T2DM) research.
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Fasiglifam hemihydrate
0 ImagesCat. No.: HY-W010655CAS No.: 1374598-80-7Synonyms: TAK-875 hemihydrateFasiglifam (TAK-875) hemihydrate is a potent, selective and orally active GPR40 agonist with EC50 of 72 nM. Fasiglifam enhances glucose-dependent insulin secretion and improves hyperglycemia in type 2 diabetic rats. Fasiglifam can induce liver injury.
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GPR120 Agonist 2 (Standard)
0 ImagesCat. No.: HY-111353RCAS No.: 1234844-11-1GPR120 Agonist 2 (Standard) is the analytical standard of GPR120 Agonist 2 (HY-111353). This product is intended for research and analytical applications. GPR120 Agonist 2 (example 206) is a GPR120 agonist that can be uesd for the study of type II diabetes and diseases associated with poor glycemic control.
